Functional Interaction between Oct-1 and Retinoid X Receptor

Retinoid X Receptor Agonists Impair

Interaction between Retinoid Acid Receptor-Related Orphan Receptor Alpha (RORA) and Neuropeptide S Receptor 1 (NPSR1) in Asthma

Retinoid acid receptor-related Orphan Receptor Alpha (RORA) was recently identified as a susceptibility gene for asthma in a genome-wide association study. To investigate the impact of RORA on asthma susceptibility, we performed a genetic association study between RORA single nucleotide polymorphisms (SNPs) in the vicinity of the asthma-associated SNP (rs11071559) and asthma-related traits. Bec...

Thyroid hormone-mediated enhancement of heterodimer formation between thyroid hormone receptor beta and retinoid X receptor.

A subset of nuclear receptors, including those for thyroid hormone (TR), retinoic acid, vitamin D3, and eicosanoids, can form heterodimers with the retinoid X receptor (RXR) on DNA regulatory elements in the absence of their cognate ligands. In a mammalian two-hybrid assay, we have found that recruitment of a VP16-RXR chimera by a Gal4-TRbeta ligand-binding domain fusion is enhanced up to 50-fo...

Retinoid X receptor-antagonistic diazepinylbenzoic acids.

Several dibenzodiazepine derivatives were identified as novel retinoid X receptor (RXR) antagonists on the basis of inhibitory activity on retinoid-induced cell differentiation of human promyelocytic leukemia cells HL-60 and transactivation assay using retinoic acid receptors (RARs) and RXRs in COS-1 cells. 4-(5H-2,3-(2,5-Dimethyl-2,5-hexano)-5-n- propyldibenzo[b,e][1,4]diazepin-11-yl)benzoic a...

Functional interaction between Trace Amine Associated Receptor 1 (TAAR1) and dopamine D2 receptor

Department of Neuroscience and Brain Technologies, Italian Institute of Technology, Genoa, 16163, Italy, (S.E., R.R.G., T.D.S.); Department of Cell Biology, Duke University, Durham, 27710, NC, USA; (L.S.B., M.G.C., R.R.G.); Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada (A.S.); INSERM UMR 1037, Cancer Research Center of Toulouse and Université de Toulouse III,...